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We found that FAD mice displayed a higher uptake of F-HPA-12 in the brain, independently from the APOE4 or APOE3 genetic background. Distribution and metabolism of F-HPA-12, a radio-fluorinated version of the ceramide analog N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl) dodecanamide, was investigated in the brain of AD transgenic mouse models (FAD) on an APOE4 or APOE3 genetic background, by positron emission tomography and by gamma counter. However, how the ceramide metabolism changes over time in AD, in vivo, remains unknown. The metabolism of ceramides is deregulated in the brain of Alzheimer’s disease (AD) patients and is associated with apolipoprotein (APO) APOE4 and amyloid-β pathology.
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